GRE Exam Numerical Ability Algebra

If x^5*y^4*z^2 <0 , which of the following must be true?
Select ALL such statements.

A. xy < 0
B. yz < 0
C. xz < 0
D. x < 0
E. x^5 < 0

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GRE Other Question

What is the average (arithmetic mean) of all the multiples of seven from 200 to 400 inclusive? If the product of 8 integers is negative, at most how many of the integers can be negative?