exam Maths Puzzle Numerical Ability

Can you help me solve.

4x^4 - 3xy^3 when x = -1 and y= -2

thanks

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exam Other Question

on the same page I don't understand the difference between problem 5 and 6 and how I get the answer for each. Problem 16 that i got wrong

Find the slope of any line perpendicular to the line through points (0,5) and (-3, -4)